A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c+ cells

A CD1c lipid agnostic T cell receptor bispecific engager redirects T cells against CD1c+ cells

IntroductionImmunotherapy is emerging as an efficacious treatment for some cancers, complementing traditional chemo-radiation therapies. Specific markers at the cell surface of cancer cells can be used as immunotherapy targets. However, many of these markers are defined by a patient’s genetic backgr...

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Bibliographic Details
Main Authors: Rita Szoke-Kovacs, Sophie Khakoo, Victor Lopes Rangel, Pietro Della Cristina, Johanne Pentier, Rahul Khanolkar, Sam El-Ajouz, Robert Simmons, David K. Cole, Peter Gogolak, Mariolina Salio, Vijaykumar Karuppiah
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
T cell receptor
bispecifics
T cell engager
CD1c
lipids
leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614610/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1614610/full

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