Infrared thermal modulation endoscopy for label-free tumor detection
Abstract In optical imaging of solid tumors, signal contrasts derived from inherent tissue temperature differences have been employed to distinguish tumor masses from surrounding tissue. Moreover, with the advancement of active infrared imaging, dynamic thermal characteristics in response to exogeno...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-76173-8 |
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| author | Suhyeon Kim Gyungseok Oh Young Ro Kim Euiheon Chung Hyuk-Sang Kwon |
| author_facet | Suhyeon Kim Gyungseok Oh Young Ro Kim Euiheon Chung Hyuk-Sang Kwon |
| author_sort | Suhyeon Kim |
| collection | DOAJ |
| description | Abstract In optical imaging of solid tumors, signal contrasts derived from inherent tissue temperature differences have been employed to distinguish tumor masses from surrounding tissue. Moreover, with the advancement of active infrared imaging, dynamic thermal characteristics in response to exogenous thermal modulation (heating and cooling) have been proposed as novel measures of tumor assessment. Contrast factors such as the average rate of temperature changes and thermal recovery time constants have been investigated through an active thermal modulation imaging approach, yielding promising tumor characterization results in a xenograft mouse model. Here, to assess its clinical potential, we developed and deployed an endoscopic infrared thermal modulation imaging system, incorporating anti-reflection germanium lenses. Employing tissue cooling, we evaluated the feasibility of detecting in situ tumors in a syngeneic rectal tumor mouse model. Consequently, early-stage tumors were successfully localized and evaluated based on their heat signatures. Notably, tumors exhibited a higher rate of temperature change induced by thermal modulation compared to adjacent tissues. Through the introduction of this label-free technology, Infrared Thermal Modulation Endoscopy (ITME), our study showcased an effective method for optically delineating and assessing solid tumors. This innovative diagnostic technology holds significant promise for enhancing our ability to detect, classify, and characterize abnormal tissues. |
| format | Article |
| id | doaj-art-85b75193a60442daa1f0283ee8372f7a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-85b75193a60442daa1f0283ee8372f7a2025-01-05T12:27:21ZengNature PortfolioScientific Reports2045-23222024-12-011411910.1038/s41598-024-76173-8Infrared thermal modulation endoscopy for label-free tumor detectionSuhyeon Kim0Gyungseok Oh1Young Ro Kim2Euiheon Chung3Hyuk-Sang Kwon4Department of Biomedical Science and Engineering, Gwangju Institute of Science and TechnologyMedical Technology Examination Division, Korean Intellectual Property OfficeAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and TechnologyDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and TechnologyAbstract In optical imaging of solid tumors, signal contrasts derived from inherent tissue temperature differences have been employed to distinguish tumor masses from surrounding tissue. Moreover, with the advancement of active infrared imaging, dynamic thermal characteristics in response to exogenous thermal modulation (heating and cooling) have been proposed as novel measures of tumor assessment. Contrast factors such as the average rate of temperature changes and thermal recovery time constants have been investigated through an active thermal modulation imaging approach, yielding promising tumor characterization results in a xenograft mouse model. Here, to assess its clinical potential, we developed and deployed an endoscopic infrared thermal modulation imaging system, incorporating anti-reflection germanium lenses. Employing tissue cooling, we evaluated the feasibility of detecting in situ tumors in a syngeneic rectal tumor mouse model. Consequently, early-stage tumors were successfully localized and evaluated based on their heat signatures. Notably, tumors exhibited a higher rate of temperature change induced by thermal modulation compared to adjacent tissues. Through the introduction of this label-free technology, Infrared Thermal Modulation Endoscopy (ITME), our study showcased an effective method for optically delineating and assessing solid tumors. This innovative diagnostic technology holds significant promise for enhancing our ability to detect, classify, and characterize abnormal tissues.https://doi.org/10.1038/s41598-024-76173-8Tumor detectionThermal endoscopyThermal modulationInfrared imagingThermal contrastRectal tumor model |
| spellingShingle | Suhyeon Kim Gyungseok Oh Young Ro Kim Euiheon Chung Hyuk-Sang Kwon Infrared thermal modulation endoscopy for label-free tumor detection Scientific Reports Tumor detection Thermal endoscopy Thermal modulation Infrared imaging Thermal contrast Rectal tumor model |
| title | Infrared thermal modulation endoscopy for label-free tumor detection |
| title_full | Infrared thermal modulation endoscopy for label-free tumor detection |
| title_fullStr | Infrared thermal modulation endoscopy for label-free tumor detection |
| title_full_unstemmed | Infrared thermal modulation endoscopy for label-free tumor detection |
| title_short | Infrared thermal modulation endoscopy for label-free tumor detection |
| title_sort | infrared thermal modulation endoscopy for label free tumor detection |
| topic | Tumor detection Thermal endoscopy Thermal modulation Infrared imaging Thermal contrast Rectal tumor model |
| url | https://doi.org/10.1038/s41598-024-76173-8 |
| work_keys_str_mv | AT suhyeonkim infraredthermalmodulationendoscopyforlabelfreetumordetection AT gyungseokoh infraredthermalmodulationendoscopyforlabelfreetumordetection AT youngrokim infraredthermalmodulationendoscopyforlabelfreetumordetection AT euiheonchung infraredthermalmodulationendoscopyforlabelfreetumordetection AT hyuksangkwon infraredthermalmodulationendoscopyforlabelfreetumordetection |