Characterizing PSMA heterogeneity in prostate cancer and identifying clinically actionable tumor associated antigens in PSMA negative cases

Characterizing PSMA heterogeneity in prostate cancer and identifying clinically actionable tumor associated antigens in PSMA negative cases

Abstract Prostate-specific membrane antigen (PSMA)-targeted theranostics have profoundly reshaped prostate cancer (PCa) management. However, patterns of PSMA expression heterogeneity and the identification of alternative targets for PSMA-negative cases remain insufficiently understood. To address th...

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Bibliographic Details
Main Authors: Yelin Mulati, Qi Shen, Yuxuan Tian, Yuke Chen, Kaifeng Yao, Wei Yu, Yunpeng Cui, Xuedong Shi, Zhisong He, Qian Zhang, Yu Fan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Prostate cancer
Prostate-specific membrane antigen
Heterogeneity
Tumor-associated antigen
Online Access:https://doi.org/10.1038/s41598-025-06393-z
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