Epitope-Driven Vaccine Development for Zika Virus: A Bioinformatics Approach
Zika virus (ZIKV) has become a global concern in 2015-2016, which can infect adults and developing fetuses. ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-strande...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Poltekkes Kemenkes Yogyakarta
2024-12-01
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| Series: | Jurnal Teknologi Laboratorium |
| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/518 |
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| Summary: | Zika virus (ZIKV) has become a global concern in 2015-2016, which can infect adults and developing fetuses. ZIKV is a member of the Flaviviridae family, which can spread through Aedes mosquitoes, sexual intercourse, from mother to fetus, and blood transfusions. The genetic material is single-stranded RNA with positive polarity. Conventional vaccine development requires a long time and significant resources, so the bioinformatics approach is an efficient alternative for identifying B cell epitopes as vaccine candidates. This research uses bioinformatics or In silico methods to identify B cell epitopes with the immune epitope database (IEDB) web server. This research showed that the peptide sequence of "EWFHDIPLPWHAGADTGTPHWNNKEA" (peptide 6E) in the envelope protein E of ZIKV is a potential vaccine candidate. This peptide is predicted to have high antigenicity, non-allergenicity and non-toxicity. This study concluded that peptide 6E is a promising vaccine candidate. Further studies are needed in vitro and in vivo to reconfirm that it can be used as a potential ZIKV vaccine candidate and can be applied in the future. |
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| ISSN: | 2338-5634 2580-0191 |