DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma

DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma

Abstract Background Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies suggest a survival advantage for gcGB patients, the un...

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Main Authors: Pinar Cakmak, Philipp Jurmeister, Iris Divé, Pia S. Zeiner, Joachim P. Steinbach, Tim R. Fenton, Karl H. Plate, Marcus Czabanka, Patrick N. Harter, Katharina J. Weber
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Clinical Epigenetics
Subjects:
Giant cell glioblastoma
Epigenetic aging
DNA methylation age acceleration
Pediatric-type high-grade glioma
Online Access:https://doi.org/10.1186/s13148-024-01793-w
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https://doi.org/10.1186/s13148-024-01793-w

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