IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES
Background: In this study it was aimed to evaluate the efficacy and timing with technique of the source control for the subgroup of septic shock (SS) patients with intraabdominal infections (IAI) in a tertiary-care educational hospital. Methods: Patients who had SS with IAI and consulted by Infe...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2024-06-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/mjhid/article/view/5630 |
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| author | Uğur Önal Deniz Akyol Olcay Buse Kenanoğlu Merve Mert Dilşah Başkol Seichan Chousein Memetali Gamze Şanlıdağ Cansu Bulut Arda Kaya Ayşe Uyan Önal Nazlıhan Yalçın Günel Guliyeva Şükrü Dirik Oğuzhan Acet Damla Akdağ Melike Demir Osman Bozbıyık Berk Göktepe Tufan Gümüş İlkin Çankayalı Kubilay Demirağ Mehmet Uyar Hilal Sipahi Hüseyin Aytaç Erdem Meltem Işıkgöz Taşbakan Bilgin Arda Şöhret Aydemir Sercan Ulusoy Oğuz Reşat Sipahi |
| author_facet | Uğur Önal Deniz Akyol Olcay Buse Kenanoğlu Merve Mert Dilşah Başkol Seichan Chousein Memetali Gamze Şanlıdağ Cansu Bulut Arda Kaya Ayşe Uyan Önal Nazlıhan Yalçın Günel Guliyeva Şükrü Dirik Oğuzhan Acet Damla Akdağ Melike Demir Osman Bozbıyık Berk Göktepe Tufan Gümüş İlkin Çankayalı Kubilay Demirağ Mehmet Uyar Hilal Sipahi Hüseyin Aytaç Erdem Meltem Işıkgöz Taşbakan Bilgin Arda Şöhret Aydemir Sercan Ulusoy Oğuz Reşat Sipahi |
| author_sort | Uğur Önal |
| collection | DOAJ |
| description |
Background: In this study it was aimed to evaluate the efficacy and timing with technique of the source control for the subgroup of septic shock (SS) patients with intraabdominal infections (IAI) in a tertiary-care educational hospital.
Methods: Patients who had SS with IAI and consulted by Infectious Diseases consultants between December 2013 and October 2022 in our centre were analyzed retrospectively.
Results: A total number of 390 patients were included. Overall day-30 mortality (OMM) was 42.5% on day 3 while day 14 and 30 mortality rates were 63.3% and 71.3%, respectively. Source control by surgical or percutaneous operation was performed in 123 of 390 cases (31.5%) and mortality rate was significantly lower in cases that were performed source control at anytime during SS (65/123-52.8% vs 213/267-79.8%, p<0.001). In 44 of 123 cases (35.7%) source control was performed during the first 12 hours and mortality was significantly lower in this group versus others (24/44-54.5% vs 254/346-73.4%, p=0.009). On the other hand, female gender (p<0.001, odds ratio(OR)=1.714-5.054, 95%CI=1.714-5.054), diabetes mellitus (p= 0.014, OR=2.284, 95%CI=1.179-4.424), carbapenem-resistant Gram-negative etiology (p=0.011, OR=4.386, 95%CI=1.398-13.759), SOFA≥10 (p<0.001, OR=3.036, 95%CI=1.802-5.114), lactate >3 mg/dl (p<0.001, OR=2.764, 95%CI=1.562-4.891) and lack of source control (p=0.001, OR=2.796, 95%CI=1.523-5.133) were significantly associated with OMM in logistic regression analysis.
Conclusions: Source control has a vital importance in terms of mortality rates for IAI related septic shock patients. Our study underscores the need for additional research, as the present analysis indicates that early source control does not manifest as a protective factor in logistic regression.
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| format | Article |
| id | doaj-art-84af9a48a23b4d8c8b404fc012386774 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-84af9a48a23b4d8c8b404fc0123867742025-01-03T00:28:00ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062024-06-0116110.4084/MJHID.2024.051IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASESUğur Önal0Deniz AkyolOlcay Buse KenanoğluMerve MertDilşah BaşkolSeichan Chousein MemetaliGamze ŞanlıdağCansu BulutArda KayaAyşe Uyan ÖnalNazlıhan YalçınGünel GuliyevaŞükrü DirikOğuzhan AcetDamla AkdağMelike DemirOsman BozbıyıkBerk GöktepeTufan Gümüşİlkin ÇankayalıKubilay DemirağMehmet UyarHilal SipahiHüseyin Aytaç ErdemMeltem Işıkgöz TaşbakanBilgin ArdaŞöhret AydemirSercan UlusoyOğuz Reşat Sipahia:1:{s:5:"en_US";s:104:"Bursa Uludag University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology";} Background: In this study it was aimed to evaluate the efficacy and timing with technique of the source control for the subgroup of septic shock (SS) patients with intraabdominal infections (IAI) in a tertiary-care educational hospital. Methods: Patients who had SS with IAI and consulted by Infectious Diseases consultants between December 2013 and October 2022 in our centre were analyzed retrospectively. Results: A total number of 390 patients were included. Overall day-30 mortality (OMM) was 42.5% on day 3 while day 14 and 30 mortality rates were 63.3% and 71.3%, respectively. Source control by surgical or percutaneous operation was performed in 123 of 390 cases (31.5%) and mortality rate was significantly lower in cases that were performed source control at anytime during SS (65/123-52.8% vs 213/267-79.8%, p<0.001). In 44 of 123 cases (35.7%) source control was performed during the first 12 hours and mortality was significantly lower in this group versus others (24/44-54.5% vs 254/346-73.4%, p=0.009). On the other hand, female gender (p<0.001, odds ratio(OR)=1.714-5.054, 95%CI=1.714-5.054), diabetes mellitus (p= 0.014, OR=2.284, 95%CI=1.179-4.424), carbapenem-resistant Gram-negative etiology (p=0.011, OR=4.386, 95%CI=1.398-13.759), SOFA≥10 (p<0.001, OR=3.036, 95%CI=1.802-5.114), lactate >3 mg/dl (p<0.001, OR=2.764, 95%CI=1.562-4.891) and lack of source control (p=0.001, OR=2.796, 95%CI=1.523-5.133) were significantly associated with OMM in logistic regression analysis. Conclusions: Source control has a vital importance in terms of mortality rates for IAI related septic shock patients. Our study underscores the need for additional research, as the present analysis indicates that early source control does not manifest as a protective factor in logistic regression. https://www.mjhid.org/mjhid/article/view/5630Septic shockIntra-abdominal infectionSource control |
| spellingShingle | Uğur Önal Deniz Akyol Olcay Buse Kenanoğlu Merve Mert Dilşah Başkol Seichan Chousein Memetali Gamze Şanlıdağ Cansu Bulut Arda Kaya Ayşe Uyan Önal Nazlıhan Yalçın Günel Guliyeva Şükrü Dirik Oğuzhan Acet Damla Akdağ Melike Demir Osman Bozbıyık Berk Göktepe Tufan Gümüş İlkin Çankayalı Kubilay Demirağ Mehmet Uyar Hilal Sipahi Hüseyin Aytaç Erdem Meltem Işıkgöz Taşbakan Bilgin Arda Şöhret Aydemir Sercan Ulusoy Oğuz Reşat Sipahi IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES Mediterranean Journal of Hematology and Infectious Diseases Septic shock Intra-abdominal infection Source control |
| title | IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES |
| title_full | IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES |
| title_fullStr | IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES |
| title_full_unstemmed | IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES |
| title_short | IMPORTANCE OF SOURCE CONTROL IN THE SUBGROUP OF INTRA-ABDOMINAL INFECTIONS FOR SEPTIC SHOCK PATIENTS: ANALYSIS OF 390 CASES |
| title_sort | importance of source control in the subgroup of intra abdominal infections for septic shock patients analysis of 390 cases |
| topic | Septic shock Intra-abdominal infection Source control |
| url | https://www.mjhid.org/mjhid/article/view/5630 |
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