Research progress of gut microbiome and diabetic nephropathy
Diabetic nephropathy is an important complication of diabetic microvascular injury, and it is also an important cause of end-stage renal disease. Its high prevalence and disability rate significantly impacts patients’ quality of life while imposing substantial social and economic burdens. Gut microb...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1490314/full |
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| author | Chenling Chu Tapas Ranjan Behera Ying Huang Wenhui Qiu Jiayi Chen Quanquan Shen Quanquan Shen |
| author_facet | Chenling Chu Tapas Ranjan Behera Ying Huang Wenhui Qiu Jiayi Chen Quanquan Shen Quanquan Shen |
| author_sort | Chenling Chu |
| collection | DOAJ |
| description | Diabetic nephropathy is an important complication of diabetic microvascular injury, and it is also an important cause of end-stage renal disease. Its high prevalence and disability rate significantly impacts patients’ quality of life while imposing substantial social and economic burdens. Gut microbiota affects host metabolism, multiple organ functions, and regulates host health throughout the life cycle. With the rapid development of technology, researchers have found that gut microbiota is closely related to the progression of diabetic kidney disease. This review explores the role of gut microbiome in diabetic nephropathy summarizing proposed mechanisms of progression and focusing on microbial metabolites, intestinal barrier disruption, inflammation, filtration barrier damage and renal fibrosis. This review also examines the mechanism and limitations of current treatments, including drugs, fecal microbiota transplantation, and lifestyle changes, offering new perspectives on prevention and treatment. |
| format | Article |
| id | doaj-art-8495418ed9f645f4b62521bb1c18871f |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-8495418ed9f645f4b62521bb1c18871f2025-01-07T14:32:28ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-12-011110.3389/fmed.2024.14903141490314Research progress of gut microbiome and diabetic nephropathyChenling Chu0Tapas Ranjan Behera1Ying Huang2Wenhui Qiu3Jiayi Chen4Quanquan Shen5Quanquan Shen6Department of Clinical Medicine, Hangzhou Normal University, Hangzhou, ChinaDepartment of Cancer Biology, Cleveland Clinic, Cleveland, OH, United StatesDepartment of Public Health and Preventive Medicine, Hangzhou Medical College, Hangzhou, ChinaDepartment of Basic Medicine and Forensic Medicine, Hangzhou Medical College, Hangzhou, ChinaDepartment of Clinical Medicine, Hangzhou Normal University, Hangzhou, ChinaDepartment of Nephrology, Zhejiang Provincial People’s Hospital Bijie Hospital, Bijie, ChinaDepartment of Nephrology, Urology & Nephrology Center, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, ChinaDiabetic nephropathy is an important complication of diabetic microvascular injury, and it is also an important cause of end-stage renal disease. Its high prevalence and disability rate significantly impacts patients’ quality of life while imposing substantial social and economic burdens. Gut microbiota affects host metabolism, multiple organ functions, and regulates host health throughout the life cycle. With the rapid development of technology, researchers have found that gut microbiota is closely related to the progression of diabetic kidney disease. This review explores the role of gut microbiome in diabetic nephropathy summarizing proposed mechanisms of progression and focusing on microbial metabolites, intestinal barrier disruption, inflammation, filtration barrier damage and renal fibrosis. This review also examines the mechanism and limitations of current treatments, including drugs, fecal microbiota transplantation, and lifestyle changes, offering new perspectives on prevention and treatment.https://www.frontiersin.org/articles/10.3389/fmed.2024.1490314/fulldiabetic nephropathygut microbiotashort-chain fatty acidsinflammationenteric-renal axisprobiotics |
| spellingShingle | Chenling Chu Tapas Ranjan Behera Ying Huang Wenhui Qiu Jiayi Chen Quanquan Shen Quanquan Shen Research progress of gut microbiome and diabetic nephropathy Frontiers in Medicine diabetic nephropathy gut microbiota short-chain fatty acids inflammation enteric-renal axis probiotics |
| title | Research progress of gut microbiome and diabetic nephropathy |
| title_full | Research progress of gut microbiome and diabetic nephropathy |
| title_fullStr | Research progress of gut microbiome and diabetic nephropathy |
| title_full_unstemmed | Research progress of gut microbiome and diabetic nephropathy |
| title_short | Research progress of gut microbiome and diabetic nephropathy |
| title_sort | research progress of gut microbiome and diabetic nephropathy |
| topic | diabetic nephropathy gut microbiota short-chain fatty acids inflammation enteric-renal axis probiotics |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1490314/full |
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