FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes

FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes

<b>Background:</b> It has been demonstrated that the concept of infinite absorption time, associated with the absorption rate constant, which drives a drug’s gastrointestinal absorption rate, is not physiologically sound. The recent analysis of oral drug absorption data based on the fini...

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Bibliographic Details
Main Authors: Elias Toulitsis, Athanasios A. Tsekouras, Panos Macheras
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Pharmaceutics
Subjects:
finite absorption time
oral administration
fraction absorbed
bioavailability
levonorgestrel
amlodipine
Online Access:https://www.mdpi.com/1999-4923/16/11/1435
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