Cycloastragenol promotes dorsal column axon regeneration in mice
IntroductionCycloastragenol (CAG) has a wide range of pharmacological effects, including anti-inflammatory, antiaging, antioxidative, and antitumorigenic properties. In addition, our previous study showed that CAG administration can promote axonal regeneration in peripheral neurons. However, whether...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2024.1424137/full |
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| author | Tao Zihan Tao Zihan Teng Wenwen Teng Wenwen Ma Yanxia Saijilafu |
| author_facet | Tao Zihan Tao Zihan Teng Wenwen Teng Wenwen Ma Yanxia Saijilafu |
| author_sort | Tao Zihan |
| collection | DOAJ |
| description | IntroductionCycloastragenol (CAG) has a wide range of pharmacological effects, including anti-inflammatory, antiaging, antioxidative, and antitumorigenic properties. In addition, our previous study showed that CAG administration can promote axonal regeneration in peripheral neurons. However, whether CAG can activate axon regeneration central nervous system (CNS) remains unknown.MethodsHere, we established a novel mouse model for visualizing spinal cord dorsal column axon regeneration involving the injection of AAV2/9-Cre into the lumbar 4/5 dorsal root ganglion (DRG) of Rosa-tdTomato reporter mice. We then treated mice by intraperitoneal administration of CAG.ResultsOur results showed that intraperitoneal CAG injections significantly promoted the growth of vitro-cultured DRG axons as well as the growth of dorsal column axons over the injury site in spinal cord injury (SCI) mice. Our results further indicate that CAG administration can promote the recovery of sensory and urinary function in SCI mice.ConclusionTogether, our findings highlight the therapeutic potential of CAG in spinal cord injury repair. |
| format | Article |
| id | doaj-art-844bc26365934791bfa4f482a0202d31 |
| institution | Kabale University |
| issn | 1662-5102 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj-art-844bc26365934791bfa4f482a0202d312025-01-03T06:47:02ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022025-01-011810.3389/fncel.2024.14241371424137Cycloastragenol promotes dorsal column axon regeneration in miceTao Zihan0Tao Zihan1Teng Wenwen2Teng Wenwen3Ma Yanxia4 Saijilafu5Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaOrthopaedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaOrthopaedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaOrthopaedic Institute, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, ChinaKey Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, School of Medicine, Hangzhou City University, Hangzhou, ChinaIntroductionCycloastragenol (CAG) has a wide range of pharmacological effects, including anti-inflammatory, antiaging, antioxidative, and antitumorigenic properties. In addition, our previous study showed that CAG administration can promote axonal regeneration in peripheral neurons. However, whether CAG can activate axon regeneration central nervous system (CNS) remains unknown.MethodsHere, we established a novel mouse model for visualizing spinal cord dorsal column axon regeneration involving the injection of AAV2/9-Cre into the lumbar 4/5 dorsal root ganglion (DRG) of Rosa-tdTomato reporter mice. We then treated mice by intraperitoneal administration of CAG.ResultsOur results showed that intraperitoneal CAG injections significantly promoted the growth of vitro-cultured DRG axons as well as the growth of dorsal column axons over the injury site in spinal cord injury (SCI) mice. Our results further indicate that CAG administration can promote the recovery of sensory and urinary function in SCI mice.ConclusionTogether, our findings highlight the therapeutic potential of CAG in spinal cord injury repair.https://www.frontiersin.org/articles/10.3389/fncel.2024.1424137/fullcycloastragenoldorsal columnaxon growthnerve injuryfunctional recoveryTERT |
| spellingShingle | Tao Zihan Tao Zihan Teng Wenwen Teng Wenwen Ma Yanxia Saijilafu Cycloastragenol promotes dorsal column axon regeneration in mice Frontiers in Cellular Neuroscience cycloastragenol dorsal column axon growth nerve injury functional recovery TERT |
| title | Cycloastragenol promotes dorsal column axon regeneration in mice |
| title_full | Cycloastragenol promotes dorsal column axon regeneration in mice |
| title_fullStr | Cycloastragenol promotes dorsal column axon regeneration in mice |
| title_full_unstemmed | Cycloastragenol promotes dorsal column axon regeneration in mice |
| title_short | Cycloastragenol promotes dorsal column axon regeneration in mice |
| title_sort | cycloastragenol promotes dorsal column axon regeneration in mice |
| topic | cycloastragenol dorsal column axon growth nerve injury functional recovery TERT |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2024.1424137/full |
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