右美托咪定受体依赖性增强巨噬细胞吞噬功能
【目的】研究右美托咪定对巨噬细胞吞噬功能的影响并探讨其可能的机制。【方法】RAW264.7细胞分成对照组(control)、右美托咪定组(DEX)、BRL44408+右美托咪定组(BRL44408+DEX)。Western blotting检测α2A肾上腺素受体、p-Akt、Akt的表达,Phagocytosis Assay Kit(IgG PE)检测巨噬细胞的吞噬能力。【结果】RAW264.7细胞上有α2A肾上腺素受体的表达;右美托咪定能够增强巨噬细胞的吞噬能力(P<0.001),BRL44408逆转巨噬细胞吞噬能力的增强(P<0.001);右美托咪定使RAW264.7细胞的A...
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Main Authors: | 吴珊, 罗刚健, 姚伟锋, 蔡珺, 黑子清 |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2020-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43566162/ |
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