Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combination enhanced Ros storm

Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combination enhanced Ros storm

Abstract Background Cancer treatment commonly involves radiation as a primary therapy, affecting nearly two-thirds of patients. The use of combination therapies is gaining traction, with the aim of achieving synergistic effects through the pharmacological interactions of multiple treatments. Methods...

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Bibliographic Details
Main Authors: Yonghui Su, Dongqun Guo, Yinghao Liang, Tuerdimaimaiti Meiheriban, Siyu Chen, Qian Tang, Xiqian Chen, Yan Huang, Jianqiao Zhong, Zongjunlin Liu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
Tumor targeting
Tumor microenvironment triggered
H2O2 generation and GSH depletion
Fenton-like reaction
Synergistic therapy
Online Access:https://doi.org/10.1186/s12951-025-03636-z
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