Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity

Bioengineered platelet nanoplatform enables renal-targeted dexamethasone delivery for chronic nephritis therapy with dual anti-inflammatory/anti-fibrotic effects and minimized systemic toxicity

Chronic nephritis management remains challenging due to the compromised therapeutic efficacy and severe systemic complications of conventional glucocorticoid therapy. Here, we developed a bioinspired platelet-mediated delivery system (LN-DEX@PLT) that leverages platelet tropism toward injured glomer...

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Bibliographic Details
Main Authors: Lingling Zhang, Haifeng Gong, Xuelian Gong, Bing Zhou, Xijian Wang, Shengnan Fei, Donglin Xia, Chunyang Xu, Xinzhong Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-10-01
Series:Bioactive Materials
Subjects:
Precision therapy
Chronic nephritis
Dexamethasone
Platelets
Minimized senescence effects
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25002300
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