Role of paraoxonase 2 (PON2) as a potential biomarker and therapeutic target in cancer treatment

Abstract Purpose Paraoxonase 2 (PON2), a mitochondrial antioxidant enzyme, is widely expressed across body tissues and plays vital roles in cellular defence. Growing evidence links its dysregulation to oxidative stress and cancer progression. This narrative review aims to elucidate PON2’s enzymatic...

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Bibliographic Details
Main Authors: Vinayak Agarwal, Matthew Cheesman, Alison Haywood, Sohil Khan, Shailendra Anoopkumar Dukie
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Journal of Cancer Research and Clinical Oncology
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Online Access:https://doi.org/10.1007/s00432-025-06282-y
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