Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

Overcoming resistance to arginine deprivation therapy using GC7 in pleural mesothelioma

Summary: Pleural mesothelioma is a highly chemotherapy-resistant cancer. Approximately 50% of mesotheliomas do not express argininosuccinate synthetase 1 (ASS1), the rate-limiting enzyme in arginine biosynthesis, making arginine depletion with pegylated arginine deiminase (ADI-PEG20) an attractive t...

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Bibliographic Details
Main Authors: Josephine Carpentier, Marta Freitas, Valle Morales, Katiuscia Bianchi, John Bomalaski, Peter Szlosarek, Sarah A. Martin
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Systems biology
Cancer systems biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027524
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