A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbate...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-12-01
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| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | https://doi.org/10.1371/journal.pntd.0012767 |
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| author | Alexei Yu Kostygov Danyil Grybchuk Senne Heeren Evgeny S Gerasimov Donnamae Klocek Aditya Reddy Jovana Sádlová Lenka Pacáková Alain Kohl František Stejskal Petr Volf Jean-Claude Dujardin Vyacheslav Yurchenko |
| author_facet | Alexei Yu Kostygov Danyil Grybchuk Senne Heeren Evgeny S Gerasimov Donnamae Klocek Aditya Reddy Jovana Sádlová Lenka Pacáková Alain Kohl František Stejskal Petr Volf Jean-Claude Dujardin Vyacheslav Yurchenko |
| author_sort | Alexei Yu Kostygov |
| collection | DOAJ |
| description | Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses. |
| format | Article |
| id | doaj-art-83c18bf8086f4b18a2f3a0fca1b17749 |
| institution | Kabale University |
| issn | 1935-2727 1935-2735 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj-art-83c18bf8086f4b18a2f3a0fca1b177492025-01-17T05:32:31ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352024-12-011812e001276710.1371/journal.pntd.0012767A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus.Alexei Yu KostygovDanyil GrybchukSenne HeerenEvgeny S GerasimovDonnamae KlocekAditya ReddyJovana SádlováLenka PacákováAlain KohlFrantišek StejskalPetr VolfJean-Claude DujardinVyacheslav YurchenkoLeishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.https://doi.org/10.1371/journal.pntd.0012767 |
| spellingShingle | Alexei Yu Kostygov Danyil Grybchuk Senne Heeren Evgeny S Gerasimov Donnamae Klocek Aditya Reddy Jovana Sádlová Lenka Pacáková Alain Kohl František Stejskal Petr Volf Jean-Claude Dujardin Vyacheslav Yurchenko A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. PLoS Neglected Tropical Diseases |
| title | A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. |
| title_full | A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. |
| title_fullStr | A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. |
| title_full_unstemmed | A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. |
| title_short | A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus. |
| title_sort | novel strain of leishmania braziliensis harbors not a toti but a bunyavirus |
| url | https://doi.org/10.1371/journal.pntd.0012767 |
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