The Research Progress of Monoclonal Antibody Labeled with 89Zr
Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progre...
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Editorial Board of Journal of Isotopes
2025-04-01
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| Series: | Journal of Isotopes |
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| Online Access: | https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.093 |
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| author | Zhanxiong XIAO Fei DUAN Hongyu LI |
| author_facet | Zhanxiong XIAO Fei DUAN Hongyu LI |
| author_sort | Zhanxiong XIAO |
| collection | DOAJ |
| description | Zirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progress has been made in the research of 89Zr-labeled monoclonal antibodies (mAbs)，driven by the development of mAb therapies. Currently，some of these mAb drugs have entered clinical phases II and III. In the labeling methods of 89Zr，deferoxamine B (DFO) is the most commonly used chelator and has been applied in clinical research. However，researchers are still continually exploring better ligands. In terms of chelator-mAb conjugation techniques，various forms of DFO derivatives remain the primary focus of research. In this article，89Zr labeling methods，chelator conjugation techniques，and advances in 89Zr-mAbs were reviewed. The challenges，issues，and future trends of 89Zr-mAbs has also been discussed and prospected. |
| format | Article |
| id | doaj-art-83b5931a068e4a5ca64db4fc6c6c628f |
| institution | Kabale University |
| issn | 1000-7512 |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Editorial Board of Journal of Isotopes |
| record_format | Article |
| series | Journal of Isotopes |
| spelling | doaj-art-83b5931a068e4a5ca64db4fc6c6c628f2025-08-20T03:44:57ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75122025-04-0138219520510.7538/tws.2024.youxian.093202409093The Research Progress of Monoclonal Antibody Labeled with 89ZrZhanxiong XIAO0Fei DUAN1Hongyu LI2Research and Development Center for Nuclear Technology (Radiopharmaceutical Engineering Transformation) of China Atomic Energy Authority, Beijing 102413, ChinaResearch and Development Center for Nuclear Technology (Radiopharmaceutical Engineering Transformation) of China Atomic Energy Authority, Beijing 102413, ChinaResearch and Development Center for Nuclear Technology (Radiopharmaceutical Engineering Transformation) of China Atomic Energy Authority, Beijing 102413, ChinaZirconium-89 (89Zr) is a metallic positron-emitting radionuclide. The relatively long half-life and moderate energy making 89Zr especially suitable for the labeling of large biomolecules such as antibodies for radioimmuno-PET (positron emission tomography) imaging. In recent years，significant progress has been made in the research of 89Zr-labeled monoclonal antibodies (mAbs)，driven by the development of mAb therapies. Currently，some of these mAb drugs have entered clinical phases II and III. In the labeling methods of 89Zr，deferoxamine B (DFO) is the most commonly used chelator and has been applied in clinical research. However，researchers are still continually exploring better ligands. In terms of chelator-mAb conjugation techniques，various forms of DFO derivatives remain the primary focus of research. In this article，89Zr labeling methods，chelator conjugation techniques，and advances in 89Zr-mAbs were reviewed. The challenges，issues，and future trends of 89Zr-mAbs has also been discussed and prospected.https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.09389zrmonoclonal antibodypet |
| spellingShingle | Zhanxiong XIAO Fei DUAN Hongyu LI The Research Progress of Monoclonal Antibody Labeled with 89Zr Journal of Isotopes 89zr monoclonal antibody pet |
| title | The Research Progress of Monoclonal Antibody Labeled with 89Zr |
| title_full | The Research Progress of Monoclonal Antibody Labeled with 89Zr |
| title_fullStr | The Research Progress of Monoclonal Antibody Labeled with 89Zr |
| title_full_unstemmed | The Research Progress of Monoclonal Antibody Labeled with 89Zr |
| title_short | The Research Progress of Monoclonal Antibody Labeled with 89Zr |
| title_sort | research progress of monoclonal antibody labeled with 89zr |
| topic | 89zr monoclonal antibody pet |
| url | https://tws.xml-journal.net/article/doi/10.7538/tws.2024.youxian.093 |
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