Identification of host cell surface proteins inhibiting furin dependent proteolytic processing of viral glycoproteins

Abstract Proteolytic cleavage by furin-like proteases is a crucial first step in the posttranslational modification of various glycoproteins found in enveloped emerging viruses, such as SARS-CoV-2 and highly pathogenic avian influenza A viruses (IAV). Here, we explored the capacity of host cell prot...

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Bibliographic Details
Main Authors: Nathalia Williams, Mehdi Chabert, Alicia Besomi, Filo Silva, Karolina Sobiech, Mirco Schmolke
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-11164-x
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