Chemogenetic activation of Gq signaling modulates dendritic development of cortical neurons in a time- and layer-specific manner

Chemogenetic activation of Gq signaling modulates dendritic development of cortical neurons in a time- and layer-specific manner

Designer receptors exclusively activated by designer drugs (DREADDs) are established tools for modulating neuronal activity. Calcium-mobilizing DREADD hM3Dq has been widely used to enhance neuronal activity. hM3Dq activates the Gq protein signaling cascade and mimics the action of native Gq protein-...

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Bibliographic Details
Main Authors: Ina Köhler, Lisa Marie Rennau, Adriana Rehm, Julia Große, Steffen Gonda, Andrea Räk, Christian Riedel, Petra Wahle
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
S831 phosphorylation of GluA1
neurite growth
Y1472 phosphorylation of GluN2B
optogenetic stimulation
calcium imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2025.1524470/full
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