IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model

IL-17-neutralizing antibody mitigates functional and structural changes in cigarette smoke-induced COPD model

Smoking remains the main risk factor for the development of chronic obstructive pulmonary disease (COPD). The inflammatory response mediated by innate and adaptive immune cells has been described in the development and progression of the disease, and the importance of Th17 cytokines has been observe...

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Main Authors: Alyne Riani Moreira, Camila Uchoa da Silva, Leticia de Paula Costa Mattos, Jussara Jesus Simão, Veronica Camargo Berti, Luan Henrique Vasconcelos Alves, Alex Ferreira da Silva, Franciele Jesus Lima, Suellen Karoline Moreira Bezerra, Cintia Nascimento Silva, Maria Isabel Cardoso Allonso- Vale, Iolanda de Fatima Lopes Calvo Tiberio, Francine Maria Almeida, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
COPD
adaptive immune response
structural changes
respiratory mechanics
IL-17 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1641300/full
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