A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment

A GSH-consuming polymeric nanoparticles drives ferroptosis amplification and combines chemotherapy to amplify breast cancer treatment

Abstract Currently, given variations in the abnormal tumor microenvironment (TME), significant progress has been made in the treatment of breast cancer (BC) based on TME-responsive nanosystems-mediated ferroptosis. Due to inherent deficiencies such as the limited efficacy of Fe-induced catalysis, th...

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Bibliographic Details
Main Authors: Mingliang Pei, Xin Guan, Xiaodong Hou, Zhiyuan Niu, Qi Lyu, Kai Wang, Shanshan Wang, Jingkai Zhang, Yun Ke, Shuting Zhuang, Jie Chen, Huixiong Xu, Fan Yang
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Ferroptosis amplification
GSH response
Chemotherapy
Breast Cancer
Polymeric nanoparticles
Online Access:https://doi.org/10.1186/s12951-025-03569-7
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https://doi.org/10.1186/s12951-025-03569-7

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