Logic-gated and contextual control of immunotherapy for solid tumors: contrasting multi-specific T cell engagers and CAR-T cell therapies

Logic-gated and contextual control of immunotherapy for solid tumors: contrasting multi-specific T cell engagers and CAR-T cell therapies

CAR-T cell and T cell engager therapies have demonstrated transformational efficacy against hematological malignancies, but achieving efficacy in solid tumors has been more challenging, in large part because of on-target/off-tumor toxicities and sub-optimal T cell anti-tumor cytotoxic functions. Her...

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Bibliographic Details
Main Authors: Olivier Nolan-Stevaux, Richard Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
T cell bispecific antibodies
CAR-T
logic gate
OR gate
AND gate
NOT gate
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490911/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490911/full

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