SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response

SP140 inhibits STAT1 signaling, induces IFN-γ in tumor-associated macrophages, and is a predictive biomarker of immunotherapy response

Background Understanding the role and potential therapeutic targeting of tumor-associated macrophages (TAMs) is crucial to developing new biomarkers and therapeutic strategies for cancer immunotherapies. The epigenetic reader SP140 has emerged as a master regulator of macrophage transcriptional prog...

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Main Authors: Richard Carvajal, Akiva Mintz, Fatemeh Momen-Heravi, Alison Taylor, Kranthi Kiran Kishore Tanagala, Joshua Morin-Baxter, Maryum Cheema, Sunil Dubey, Angela Yoon, Yi-Shing L Cheng, Jeffrey Nickerson
Format: Article
Language:English
Published: BMJ Publishing Group 2022-12-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/10/12/e005088.full
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https://jitc.bmj.com/content/10/12/e005088.full

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