Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Bile acid 7α-dehydroxylating bacteria accelerate injury-induced mucosal healing in the colon

Abstract Host-microbiome communication is frequently perturbed in gut pathologies due to microbiome dysbiosis, leading to altered production of bacterial metabolites. Among these, 7α-dehydroxylated bile acids are notably diminished in inflammatory bowel disease patients. Herein, we investigated whet...

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Main Authors: Antoine Jalil, Alessia Perino, Yuan Dong, Jéromine Imbach, Colin Volet, Eduard Vico-Oton, Hadrien Demagny, Lucie Plantade, Hector Gallart-Ayala, Julijana Ivanisevic, Rizlan Bernier-Latmani, Siegfried Hapfelmeier, Kristina Schoonjans
Format: Article
Language:English
Published: Springer Nature 2025-03-01
Series:EMBO Molecular Medicine
Subjects:
Bile Acids
7α-dehydroxylating Bacteria
Intestinal Mucosal Healing
Ulcerative Colitis
Online Access:https://doi.org/10.1038/s44321-025-00202-w
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https://doi.org/10.1038/s44321-025-00202-w

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