Design and fabrication of a mesoporous silica scaffold for oral delivery of peptides

Design and fabrication of a mesoporous silica scaffold for oral delivery of peptides

Abstract The goal of this effort was to create mesoporous nanoparticles (MSNs) decorated with amine groups and loaded with liraglutide (LRT) for oral delivery. Amine-decorated MSNs were helpful for peptide entrapment and prolonged release of liraglutide, a GLP-1 analog. Liraglutide-loaded MSNs were...

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Main Authors: Yasir Mehmood, Hira Shahid, Rida Siddique, Umar Farooq, Syeda Momena Rizvi, Mohammad N. Uddin, Mohsin Kazi, Mohammed Bourhia, Fakhreldeen Dabiellil, Mohammed H. AL Mughram
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Solubility
Bioavailability
Mesoporous
Silica
Liraglutide
Online Access:https://doi.org/10.1038/s41598-025-12728-7
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https://doi.org/10.1038/s41598-025-12728-7

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