The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy
Background: Coenzyme Q10 (CoQ10), a key component of mitochondrial energy production and a potent antioxidant, plays an essential role in addressing oxidative stress and mitochondrial dysfunction. Its applications span cardiovascular health, infectious diseases, neurological conditions, reproductiv...
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| Format: | Article |
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Nicolaus Copernicus University in Toruń
2025-01-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/57174 |
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| author | Mateusz Górski Adrianna Załęska Mateusz Bychowski Julia Kwaśna Izabela Kaźmierczyk Kacper Lenart Michał Homza Natalia Zakrzewska Szymon Bednarek Joanna Kulicka |
| author_facet | Mateusz Górski Adrianna Załęska Mateusz Bychowski Julia Kwaśna Izabela Kaźmierczyk Kacper Lenart Michał Homza Natalia Zakrzewska Szymon Bednarek Joanna Kulicka |
| author_sort | Mateusz Górski |
| collection | DOAJ |
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Background: Coenzyme Q10 (CoQ10), a key component of mitochondrial energy production and a potent antioxidant, plays an essential role in addressing oxidative stress and mitochondrial dysfunction. Its applications span cardiovascular health, infectious diseases, neurological conditions, reproductive health, and fatigue management. However, gaps remain in understanding its optimal dosing, long-term impact, and efficacy across diverse health conditions.
Methods: This review synthesized findings from clinical trials, meta-analyses, and observational studies. A systematic search of PubMed and ScienceDirect was conducted, selecting studies based on methodological rigor and relevance to CoQ10’s mechanisms, efficacy, and safety.
Results: CoQ10 supplementation reduced cardiovascular mortality, alleviated migraine symptoms, improved mitochondrial function, and decreased oxidative stress. Promising but inconclusive evidence supports its role in managing statin-induced myopathy and enhancing reproductive outcomes. CoQ10 was consistently shown to be safe and well-tolerated.
Conclusion: CoQ10 demonstrates significant therapeutic potential across several health conditions. Its antioxidant and bioenergetic benefits are well-documented, but further research is needed to refine dosing strategies and evaluate long-term effects. CoQ10 remains a promising complementary therapy for modern health challenges.
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| format | Article |
| id | doaj-art-81c22ecb580e42d8ab695329944fef13 |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-81c22ecb580e42d8ab695329944fef132025-01-07T08:22:59ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-01-013710.12775/QS.2025.37.57174The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant TherapyMateusz Górski0https://orcid.org/0009-0003-3473-132XAdrianna Załęska1https://orcid.org/0009-0004-6772-3956Mateusz Bychowski2https://orcid.org/0009-0004-9034-2756Julia Kwaśna3https://orcid.org/0009-0006-2314-2329Izabela Kaźmierczyk4https://orcid.org/0009-0006-7798-7765Kacper Lenart5https://orcid.org/0009-0003-5092-8835Michał Homza6https://orcid.org/0009-0002-4651-5520Natalia Zakrzewska7https://orcid.org/0009-0003-0405-2764Szymon Bednarek8https://orcid.org/0009-0001-3189-8322Joanna Kulicka9https://orcid.org/0009-0009-1614-482XMedical University of LodzMedical University of Lodz, PolandMedical University of Lodz, PolandMedical University of Gdansk, PolandMedical University of Lodz, PolandMedical University of Lodz, PolandMedical University of Lodz, PolandMedical University of Lodz, PolandMedical University of Lodz, PolandMedical University of Lodz, Poland Background: Coenzyme Q10 (CoQ10), a key component of mitochondrial energy production and a potent antioxidant, plays an essential role in addressing oxidative stress and mitochondrial dysfunction. Its applications span cardiovascular health, infectious diseases, neurological conditions, reproductive health, and fatigue management. However, gaps remain in understanding its optimal dosing, long-term impact, and efficacy across diverse health conditions. Methods: This review synthesized findings from clinical trials, meta-analyses, and observational studies. A systematic search of PubMed and ScienceDirect was conducted, selecting studies based on methodological rigor and relevance to CoQ10’s mechanisms, efficacy, and safety. Results: CoQ10 supplementation reduced cardiovascular mortality, alleviated migraine symptoms, improved mitochondrial function, and decreased oxidative stress. Promising but inconclusive evidence supports its role in managing statin-induced myopathy and enhancing reproductive outcomes. CoQ10 was consistently shown to be safe and well-tolerated. Conclusion: CoQ10 demonstrates significant therapeutic potential across several health conditions. Its antioxidant and bioenergetic benefits are well-documented, but further research is needed to refine dosing strategies and evaluate long-term effects. CoQ10 remains a promising complementary therapy for modern health challenges. https://apcz.umk.pl/QS/article/view/57174Coenzyme Q10Mitochondrial FunctionOxidative StressCardiovascular HealthNeurological DiseasesAntioxidant Therapy |
| spellingShingle | Mateusz Górski Adrianna Załęska Mateusz Bychowski Julia Kwaśna Izabela Kaźmierczyk Kacper Lenart Michał Homza Natalia Zakrzewska Szymon Bednarek Joanna Kulicka The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy Quality in Sport Coenzyme Q10 Mitochondrial Function Oxidative Stress Cardiovascular Health Neurological Diseases Antioxidant Therapy |
| title | The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy |
| title_full | The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy |
| title_fullStr | The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy |
| title_full_unstemmed | The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy |
| title_short | The Role of Coenzyme Q10 in Modern Medicine: Insights into Energy Metabolism and Antioxidant Therapy |
| title_sort | role of coenzyme q10 in modern medicine insights into energy metabolism and antioxidant therapy |
| topic | Coenzyme Q10 Mitochondrial Function Oxidative Stress Cardiovascular Health Neurological Diseases Antioxidant Therapy |
| url | https://apcz.umk.pl/QS/article/view/57174 |
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