Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells

Synergistic Activation of VDR-RXR Heterodimers by Vitamin D and Rexinoids in Human Kidney and Brain Cells

The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25D), binds to the vitamin D receptor (VDR) with high affinity. The VDR then heterodimerizes with the retinoid X receptor (RXR) and associates with vitamin D response elements (VDREs) to regulate the transcription of target genes. Bexarotene (...

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Bibliographic Details
Main Authors: Mobin Emran Doost, Jennifer Hong, Jennifer E. Broatch, Michael T. Applegate, Carl E. Wagner, Pamela A. Marshall, Peter W. Jurutka
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
vitamin D receptor
vitamin D
RXR
rexinoids
synergism
polymorphisms
Online Access:https://www.mdpi.com/2073-4409/13/22/1878
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