Rapid identification of key antibiotic resistance genes in E. coli using high-resolution genome-scale CRISPRi screening

Rapid identification of key antibiotic resistance genes in E. coli using high-resolution genome-scale CRISPRi screening

Summary: Bacteria possess a vast repertoire of genes to adapt to environmental challenges. Understanding the gene fitness landscape under antibiotic stress is crucial for elucidating bacterial resistance mechanisms and antibiotic action. To explore this, we conducted a genome-scale CRISPRi screen us...

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Bibliographic Details
Main Authors: Donghui Choe, Eunju Lee, Kangsan Kim, Soonkyu Hwang, Ki Jun Jeong, Bernhard O. Palsson, Byung-Kwan Cho, Suhyung Cho
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Genetics
Molecular biology
Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006960
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