Nitroxoline is a novel inhibitor of NLRP3-dependent pyroptosis

Abstract Aberrant activity of the NLR family pyrin domain containing 3 (NLRP3) inflammasome contributes to a wide range of diseases associated with acute inflammatory responses and chronic sterile inflammation. Activation of the NLRP3 inflammasome mediates pyroptotic cell death and the release of pr...

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Bibliographic Details
Main Authors: Christina Maeder, Roberto Baumann, Susanne Gaul, Sven Fikenzer, Michael Schaefer, Hermann Kalwa, Ulrich Laufs, Alexander Kogel
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02699-z
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