Hypoxia-augmented chemotherapy potentiates imaging-guided combinatorial radionuclide-sonodynamic therapy for pancreatic cancer

Hypoxia-augmented chemotherapy potentiates imaging-guided combinatorial radionuclide-sonodynamic therapy for pancreatic cancer

Abstract Radionuclide therapy and chemotherapy are effective for pancreatic cancer, yet their efficacy is often limited by tumor hypoxia. In this study, manganese porphyrin (MnTTP) and tirapazamine (TPZ) were encapsulated in polylactic-co-glycolic acid (PLGA) spheres, which were subsequently coated...

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Main Authors: Jie An, Kaile Chu, Xirong Li, Huizhu Ma, Qin Zhou, Chenliang Niu, Jie Gao, Junping Lv, Jianbo Cao, XinYu Zhang, Haitao Zhou, Hongliang Wang, Min Li, Zhifang Wu, Sijin Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Synergistic therapeutic
Radionuclide therapy
Sonodynamic therapy
Hypoxia-activated chemotherapy
SPECT imaging
Online Access:https://doi.org/10.1186/s12951-025-03611-8
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https://doi.org/10.1186/s12951-025-03611-8

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