Dexamethasone induces transgenerational inheritance of fetal-derived glomerulosclerosis phenotype in offspring through GR/DNMT3a mediated alterations of the lncRNA-Meg3/Notch signaling pathway

Dexamethasone induces transgenerational inheritance of fetal-derived glomerulosclerosis phenotype in offspring through GR/DNMT3a mediated alterations of the lncRNA-Meg3/Notch signaling pathway

Abstract Prenatal dexamethasone exposure (PDE) has been reported to be associated with negative pregnancy outcomes and increased susceptibility to chronic diseases in their offspring. This study aimed to explore the transgenerational effects and mechanisms of renal developmental toxicity in offsprin...

Full description

Saved in:
Bibliographic Details
Main Authors: Xiaoqi Zhao, Zhaojun Wang, Zhiping Xia, Haiyun Chen, Yanan Zhu, Songdi Wang, Yan Bao, Yutang Liu, Hui Wang, Ying Ao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Transgenerational inheritance
Maternal dexamethasone exposure
Renal developmental toxicity
Epigenetic modification
Imprinted genes
LncRNA Meg3
Online Access:https://doi.org/10.1186/s12964-025-02346-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12964-025-02346-1

Similar Items