Persulfidation of Human Cystathionine <i>γ</i>-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H<sub>2</sub>S Production

Persulfidation of Human Cystathionine <i>γ</i>-Lyase Inhibits Its Activity: A Negative Feedback Regulation Mechanism for H<sub>2</sub>S Production

Cystathionine γ-lyase (CSE) is the second enzyme in the trans-sulfuration pathway that converts cystathionine to cysteine. It is also one of three major enzymes responsible for the biosynthesis of hydrogen sulfide (H<sub>2</sub>S). CSE is believed to be the major source of endogenous H&l...

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Bibliographic Details
Main Authors: Guanya Jia, Heng Li, Haisheng Gan, Jun Wang, Zhilong Zhu, Yanxiong Wang, Yongyi Ye, Xiaoya Shang, Weining Niu
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Antioxidants
Subjects:
cystathionine γ-lyase
hydrogen sulfide
persulfidation
post-translational modification
negative feedback regulation
Online Access:https://www.mdpi.com/2076-3921/13/11/1402
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