Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Cardiac Slc25a49‐Mediated Energy Reprogramming Governs Doxorubicin‐Induced Cardiomyopathy through the G6P–AP‐1–Sln Axis

Abstract Doxorubicin (Dox), a potent antitumor drug, is linked to cardiac toxicity. Few mechanism‐based therapies against cardiotoxicity are available. Dysfunction in mitochondrial energy metabolism contributes to Dox‐induced cardiomyopathy. It is aimed at exploring the association between specific...

Full description

Saved in:
Bibliographic Details
Main Authors: Sitong Wan, Jingyi Qi, Yi Xia, Chang Fan, Teng Xu, Xu Zhang, Jiaxin Shi, Chenxuan Wang, Yitong Cheng, Dongyuan Zhang, Rong Liu, Yinhua Zhu, Changchang Cao, Dekui Jin, Peng An, Yongting Luo, Junjie Luo
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
cardiomyopathy
doxorubicin
energy reprogramming
mitochondria
Slc25a49–G6P–AP‐1–Sln axis
Online Access:https://doi.org/10.1002/advs.202502163
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/advs.202502163

Similar Items