Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts

Succession of transiently active tumor‐initiating cell clones in human pancreatic cancer xenografts

Abstract Although tumor‐initiating cell (TIC) self‐renewal has been postulated to be essential in progression and metastasis formation of human pancreatic adenocarcinoma (PDAC), clonal dynamics of TICs within PDAC tumors are yet unknown. Here, we show that long‐term progression of PDAC in serial xen...

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Bibliographic Details
Main Authors: Claudia R Ball, Felix Oppel, Karl Roland Ehrenberg, Taronish D Dubash, Sebastian M Dieter, Christopher M Hoffmann, Ulrich Abel, Friederike Herbst, Moritz Koch, Jens Werner, Frank Bergmann, Naveed Ishaque, Manfred Schmidt, Christof von Kalle, Claudia Scholl, Stefan Fröhling, Benedikt Brors, Wilko Weichert, Jürgen Weitz, Hanno Glimm
Format: Article
Language:English
Published: Springer Nature 2017-05-01
Series:EMBO Molecular Medicine
Subjects:
clonal dynamics
pancreatic cancer
phenotypic plasticity
tumor‐initiating cells
Online Access:https://doi.org/10.15252/emmm.201607354
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