Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.

Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.

HIV infection and the associated chronic immune activation alter T cell homeostasis leading to CD4 T cell depletion and CD8 T cell expansion. The mechanisms behind these outcomes are not totally defined and only partially explained by the direct cytopathic effect of the virus. In this manuscript, we...

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Main Authors: Cecile Le Saout, Rebecca B Hasley, Hiromi Imamichi, Lueng Tcheung, Zonghui Hu, Megan A Luckey, Jung-Hyun Park, Scott K Durum, Mindy Smith, Adam W Rupert, Michael C Sneller, H Clifford Lane, Marta Catalfamo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-03-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1003976&type=printable
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