Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents

Uracil derivatives/ursolic acid hybrids - naturally derived compounds as anticancer agents

Abstract A series of new uracil derivatives/ursolic acid hybrids were designed and synthesised as potential cytotoxic agents. The uracil, thymine, 6-methyluracil and 2-thiouracil moieties were linked to ursolic acid (1) through alkyl chains of different lengths (either four or six -CH2- units). The...

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Main Authors: Olga Michalak, Marcin Cybulski, Marek Kubiszewski, Nataliya Finiuk, Yuliia Kozak, Dejan Milenkovic, Sylwia Żurawicka, Piotr Roszczenko, Anna Bielawska, Bartosz Trzaskowski, Agnieszka Gornowicz
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Ursolic acid
Breast cancer
Cytotoxic activity
Uracil derivatives
Molecular docking
ADME
Online Access:https://doi.org/10.1038/s41598-025-14351-y
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https://doi.org/10.1038/s41598-025-14351-y

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