HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway
Summary: Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells (hucMSCs) have been demonstrate...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224025793 |
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| author | Yang Yao Tiantian Shan Xiaoying Li |
| author_facet | Yang Yao Tiantian Shan Xiaoying Li |
| author_sort | Yang Yao |
| collection | DOAJ |
| description | Summary: Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells (hucMSCs) have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis. In this study, we utilized blood vessel organoids (BVOs) to investigate the impact of high glucose on vasculogenesis and subsequent angiogenesis. We found that BVOs in the vascular lineage induction stage were more sensitive to high glucose and more susceptible to affect endothelial cell differentiation and function. Moreover, hucMSCs can alleviate the high glucose-induced inhibition of endothelial cell differentiation and dysfunction through MAPK signaling pathway downregulation, with the MAPK activator dimethyl fumarate further illustrating the results. Thereby, we demonstrated that high glucose can lead to abnormal vasculogenesis and impact subsequent angiogenesis, and hucMSCs can alleviate this effect. |
| format | Article |
| id | doaj-art-7feeb0a903e749fba03cbc9decc3d554 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-7feeb0a903e749fba03cbc9decc3d5542024-12-22T05:29:03ZengElsevieriScience2589-00422024-12-012712111354HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathwayYang Yao0Tiantian Shan1Xiaoying Li2Department of Anesthesiology, Qingdao Municipal Hospital, School of Medicine, Qingdao University, Qingdao 266011, China; Research Center of Translational Medicine, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, ChinaResearch Center of Translational Medicine, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, China; Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao 266000, ChinaResearch Center of Translational Medicine, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, China; Department of Emergency, Jinan Central Hospital, Jinan 250013, China; Department of Emergency, Central Hospital Affiliated Shandong First Medical University, Jinan 250013, China; Corresponding authorSummary: Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells (hucMSCs) have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis. In this study, we utilized blood vessel organoids (BVOs) to investigate the impact of high glucose on vasculogenesis and subsequent angiogenesis. We found that BVOs in the vascular lineage induction stage were more sensitive to high glucose and more susceptible to affect endothelial cell differentiation and function. Moreover, hucMSCs can alleviate the high glucose-induced inhibition of endothelial cell differentiation and dysfunction through MAPK signaling pathway downregulation, with the MAPK activator dimethyl fumarate further illustrating the results. Thereby, we demonstrated that high glucose can lead to abnormal vasculogenesis and impact subsequent angiogenesis, and hucMSCs can alleviate this effect.http://www.sciencedirect.com/science/article/pii/S2589004224025793PathophysiologyStem cells researchVascular remodeling |
| spellingShingle | Yang Yao Tiantian Shan Xiaoying Li HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway iScience Pathophysiology Stem cells research Vascular remodeling |
| title | HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway |
| title_full | HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway |
| title_fullStr | HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway |
| title_full_unstemmed | HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway |
| title_short | HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway |
| title_sort | hucmscs can alleviate abnormal vasculogenesis induced by high glucose through the mapk signaling pathway |
| topic | Pathophysiology Stem cells research Vascular remodeling |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224025793 |
| work_keys_str_mv | AT yangyao hucmscscanalleviateabnormalvasculogenesisinducedbyhighglucosethroughthemapksignalingpathway AT tiantianshan hucmscscanalleviateabnormalvasculogenesisinducedbyhighglucosethroughthemapksignalingpathway AT xiaoyingli hucmscscanalleviateabnormalvasculogenesisinducedbyhighglucosethroughthemapksignalingpathway |