Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights
Kleinia is a genus of over 50 species that are commonly used in primary care in several countries. This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in Kleinia taxa, thereby promoting the development of novel, safe, and effective therapies for a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1469887/full |
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| author | Bantayehu Addis Tegegne Tesfa Begashaw Wubetu Yihunie Belay Mengistie Kassahun Tariku Tirsit Ketsela Zeleke Mohammed Jemal Mamaru Getinet Agumas Alemu Alehegn Abebe Dagne |
| author_facet | Bantayehu Addis Tegegne Tesfa Begashaw Wubetu Yihunie Belay Mengistie Kassahun Tariku Tirsit Ketsela Zeleke Mohammed Jemal Mamaru Getinet Agumas Alemu Alehegn Abebe Dagne |
| author_sort | Bantayehu Addis Tegegne |
| collection | DOAJ |
| description | Kleinia is a genus of over 50 species that are commonly used in primary care in several countries. This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in Kleinia taxa, thereby promoting the development of novel, safe, and effective therapies for a variety of illnesses. To this end, we performed a thorough search of English-language publications from PubMed, Scopus, ScienceDirect, Web of Science, Google Scholar, and ResearchGate. Our search utilized keywords such as “ethnobotany,” “geographic distribution,” “ethnomedicinal use,” “phytochemistry,” “pharmacological or bioactivities,” and “toxicological activities” related to the genus Kleinia. Chemical structures were depicted using Chemdraw® software. Literature highlights numerous Kleinia taxa used in traditional medicine for conditions like intestinal parasites, measles, smallpox, diabetes, edema, nerve disorders, sexual dysfunction, gastrointestinal issues, cancer and more. Phytochemical analysis identifies 77 secondary metabolites, mainly alkaloids, flavonoids, saponins, terpenes, and terpenoids and other miscellaneous metabolites. Among the Kleinia taxa, K. anteuphorbium, K. longiflora, K. grandiflora, K. odora, K. squarrosa, K. abyssinica, K. pendula, and K. azoides have been scientifically validated to exhibit various pharmacological activities. However, the existence of potentially harmful metabolites in Kleinia taxa, particularly pyrrolizidine alkaloids, emphasizes the significance of cautious application in traditional medicine and the need for rigorous toxicological assessments. In conclusion, this review highlights the promise of Kleinia taxa as significant medicinal resources and advocates for extensive bioprospecting. It encourages global pharmaceutical companies and academic institutions to conduct thorough investigations of the genus Kleinia to uncover new therapeutic possibilities. |
| format | Article |
| id | doaj-art-7fc91e2177e84e1299299ace47a51083 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-7fc91e2177e84e1299299ace47a510832025-01-08T06:11:49ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14698871469887Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insightsBantayehu Addis Tegegne0Tesfa Begashaw1Wubetu Yihunie Belay2Mengistie Kassahun Tariku3Tirsit Ketsela Zeleke4Mohammed Jemal5Mamaru Getinet6Agumas Alemu Alehegn7Abebe Dagne8Department of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Debre Birhan University, Debre Birhan, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markose, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Biomedical Sciences, School of Medicine, Debre Markos University, Debre Markose, EthiopiaDepartment of Biomedical Sciences, School of Medicine, Debre Markos University, Debre Markose, EthiopiaDepartment of Pharmacy, Amhara Regional State Public Health Institute, Bahir Dar, EthiopiaDepartment of Pharmacy, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, EthiopiaKleinia is a genus of over 50 species that are commonly used in primary care in several countries. This study seeks to inspire researchers to quickly discover and isolate the key active metabolites found in Kleinia taxa, thereby promoting the development of novel, safe, and effective therapies for a variety of illnesses. To this end, we performed a thorough search of English-language publications from PubMed, Scopus, ScienceDirect, Web of Science, Google Scholar, and ResearchGate. Our search utilized keywords such as “ethnobotany,” “geographic distribution,” “ethnomedicinal use,” “phytochemistry,” “pharmacological or bioactivities,” and “toxicological activities” related to the genus Kleinia. Chemical structures were depicted using Chemdraw® software. Literature highlights numerous Kleinia taxa used in traditional medicine for conditions like intestinal parasites, measles, smallpox, diabetes, edema, nerve disorders, sexual dysfunction, gastrointestinal issues, cancer and more. Phytochemical analysis identifies 77 secondary metabolites, mainly alkaloids, flavonoids, saponins, terpenes, and terpenoids and other miscellaneous metabolites. Among the Kleinia taxa, K. anteuphorbium, K. longiflora, K. grandiflora, K. odora, K. squarrosa, K. abyssinica, K. pendula, and K. azoides have been scientifically validated to exhibit various pharmacological activities. However, the existence of potentially harmful metabolites in Kleinia taxa, particularly pyrrolizidine alkaloids, emphasizes the significance of cautious application in traditional medicine and the need for rigorous toxicological assessments. In conclusion, this review highlights the promise of Kleinia taxa as significant medicinal resources and advocates for extensive bioprospecting. It encourages global pharmaceutical companies and academic institutions to conduct thorough investigations of the genus Kleinia to uncover new therapeutic possibilities.https://www.frontiersin.org/articles/10.3389/fphar.2024.1469887/fullKleiniaethnomedicinal usesphytochemicalsmetabolitesethnopharmacologytoxicology |
| spellingShingle | Bantayehu Addis Tegegne Tesfa Begashaw Wubetu Yihunie Belay Mengistie Kassahun Tariku Tirsit Ketsela Zeleke Mohammed Jemal Mamaru Getinet Agumas Alemu Alehegn Abebe Dagne Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights Frontiers in Pharmacology Kleinia ethnomedicinal uses phytochemicals metabolites ethnopharmacology toxicology |
| title | Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights |
| title_full | Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights |
| title_fullStr | Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights |
| title_full_unstemmed | Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights |
| title_short | Kleinia (Asteraceae): comprehensive review of ethnomedicinal uses, phytochemical profiles, ethnopharmacological applications, and toxicological insights |
| title_sort | kleinia asteraceae comprehensive review of ethnomedicinal uses phytochemical profiles ethnopharmacological applications and toxicological insights |
| topic | Kleinia ethnomedicinal uses phytochemicals metabolites ethnopharmacology toxicology |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1469887/full |
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