Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

Mitochondrial heteroplasmy improves risk prediction for myeloid neoplasms

Abstract Clonal hematopoiesis of indeterminate potential is the primary pathogenic risk factor for myeloid neoplasms, while heteroplasmy (mutations in a subset of cellular mitochondrial DNA) is another marker of clonal expansion associated with hematological malignancies. We explore how these two ma...

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Main Authors: Yun Soo Hong, Sergiu Pasca, Wen Shi, Daniela Puiu, Nicole J. Lake, Monkol Lek, Meng Ru, Megan L. Grove, Anna Prizment, Corinne E. Joshu, Elizabeth A. Platz, Eliseo Guallar, Dan E. Arking, Lukasz P. Gondek
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54443-3
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https://doi.org/10.1038/s41467-024-54443-3

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