Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation

Lactobacillus acidophilus extracellular vesicles-coated UiO-66-NH2@siRNA nanoparticles for ulcerative colitis targeted gene therapy and gut microbiota modulation

Abstract Ulcerative colitis (UC) is a complex and chronic inflammatory bowel disease whose pathogenesis involves genetic and environmental factors, which poses a challenge for treatment. Here, we have designed an innovative integrated therapeutic strategy using Lactobacillus acidophilus extracellula...

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Bibliographic Details
Main Authors: Chenyang Cui, Jiaze Tang, Jie Chen, Beining Zhang, Ruonan Li, Qiang Zhang, Chunjing Qiu, Rongchen Chen, Geng Min, Zhaowei Sun, Haibo Weng
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Ulcerative colitis
Lactobacillus acidophilus EVs
TNF-α SiRNA
UiO-66-NH2
Targeted gene therapy
Online Access:https://doi.org/10.1186/s12951-025-03376-0
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