The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study
Background: The emergence of multidrug-resistant organisms (MDROs) endangered neonates in the neonatal intensive care units (NICUs). Aim of the work: To identify the most common bacterial agents and MDROs in neonatal sepsis in our center, their antibiotic sensitivity, the possible associated neonat...
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Cairo University, Faculty of Medicine, Department of Pediatrics
2025-01-01
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| Series: | Pediatric Sciences Journal |
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| Online Access: | https://cupsj.journals.ekb.eg/article_401883_4da522b88fb188aec0a994d13136f3e6.pdf |
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| author | Dina Khedr Peter Samaan Abdulrahman Abdulrazek Noha Adel Yassin |
| author_facet | Dina Khedr Peter Samaan Abdulrahman Abdulrazek Noha Adel Yassin |
| author_sort | Dina Khedr |
| collection | DOAJ |
| description | Background: The emergence of multidrug-resistant organisms (MDROs) endangered neonates in the neonatal intensive care units (NICUs).
Aim of the work: To identify the most common bacterial agents and MDROs in neonatal sepsis in our center, their antibiotic sensitivity, the possible associated neonatal and maternal risk factors, and their relation to the outcome.
Subjects and Methods: This retrospective study included 138 neonates with culture-proven sepsis (blood, endotracheal tube aspirates (ETA), urine, cerebrospinal fluid (CSF), or wound swabs) admitted in 1 year (2022). Data was obtained from the patient's files, including various clinical and laboratory characteristics and risk factors and outcomes.
Results: This study included 138 newborns with confirmed neonatal sepsis. Of all cultures performed, multidrug resistant (MDR) Klebsiella pneumoniae was the most frequently isolated organism among 37 (27%) cases, that was mostly sensitive to polymyxin B was, followed by coagulase-negative Staphylococcal aureus (CoNS) in 32 cases, which was the most sensitive to vancomycin. Of all performed cultures, 71(51%) revealed MDROs (MDR Klebsiella pneumoniae, MRSA, MDR Acinetobacter, MDR Enterobacter, and MDR E. coli). The frequency of MRSA and MDR Klebsiella pneumoniae in the blood cultures was higher among those who died than those who survived (p= 0.03) and (p= 0.04) respectively. Logistic regression showed that bulging fontanel, feeding intolerance, temperature instability, long duration of admission, and high CRP were associated with high mortality among the studied cases (odd ratio > 1 (p= 0.0001), (p=0.007), (p=0.03), (p=0.001) and (p=0.006) respectively, while normal blood pressure, blood transfusion, appropriate birth weight, and normal serum albumin were protective variables (odd ratio < 1) (p= 0.008), (p=0.03), (p=0.001) and (p=0.001) respectively.
Conclusion: MDROs were isolated in more than 50% of neonatal sepsis. The methicillin- resistant Staphylococcus aureus and MDR Klebsiella pneumoniae in blood cultures were associated with higher mortality in neonatal sepsis. |
| format | Article |
| id | doaj-art-7e7e3e2d49704acc9967ba234b00c575 |
| institution | Kabale University |
| issn | 2805-279X 2682-3985 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cairo University, Faculty of Medicine, Department of Pediatrics |
| record_format | Article |
| series | Pediatric Sciences Journal |
| spelling | doaj-art-7e7e3e2d49704acc9967ba234b00c5752025-01-07T10:28:58ZengCairo University, Faculty of Medicine, Department of PediatricsPediatric Sciences Journal2805-279X2682-39852025-01-0151122210.21608/CUPSJ.2025.332619.1148The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational StudyDina Khedr0https://orcid.org/0000-0002-2112-8930Peter Samaan1https://orcid.org/0009-0004-8517-9923Abdulrahman Abdulrazek2Noha Adel Yassin3https://orcid.org/0000-0002-9297-4990Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, EgyptDepartment of Pediatrics, Faculty of Medicine, Cairo University, Cairo, EgyptBackground: The emergence of multidrug-resistant organisms (MDROs) endangered neonates in the neonatal intensive care units (NICUs). Aim of the work: To identify the most common bacterial agents and MDROs in neonatal sepsis in our center, their antibiotic sensitivity, the possible associated neonatal and maternal risk factors, and their relation to the outcome. Subjects and Methods: This retrospective study included 138 neonates with culture-proven sepsis (blood, endotracheal tube aspirates (ETA), urine, cerebrospinal fluid (CSF), or wound swabs) admitted in 1 year (2022). Data was obtained from the patient's files, including various clinical and laboratory characteristics and risk factors and outcomes. Results: This study included 138 newborns with confirmed neonatal sepsis. Of all cultures performed, multidrug resistant (MDR) Klebsiella pneumoniae was the most frequently isolated organism among 37 (27%) cases, that was mostly sensitive to polymyxin B was, followed by coagulase-negative Staphylococcal aureus (CoNS) in 32 cases, which was the most sensitive to vancomycin. Of all performed cultures, 71(51%) revealed MDROs (MDR Klebsiella pneumoniae, MRSA, MDR Acinetobacter, MDR Enterobacter, and MDR E. coli). The frequency of MRSA and MDR Klebsiella pneumoniae in the blood cultures was higher among those who died than those who survived (p= 0.03) and (p= 0.04) respectively. Logistic regression showed that bulging fontanel, feeding intolerance, temperature instability, long duration of admission, and high CRP were associated with high mortality among the studied cases (odd ratio > 1 (p= 0.0001), (p=0.007), (p=0.03), (p=0.001) and (p=0.006) respectively, while normal blood pressure, blood transfusion, appropriate birth weight, and normal serum albumin were protective variables (odd ratio < 1) (p= 0.008), (p=0.03), (p=0.001) and (p=0.001) respectively. Conclusion: MDROs were isolated in more than 50% of neonatal sepsis. The methicillin- resistant Staphylococcus aureus and MDR Klebsiella pneumoniae in blood cultures were associated with higher mortality in neonatal sepsis.https://cupsj.journals.ekb.eg/article_401883_4da522b88fb188aec0a994d13136f3e6.pdfneonatal sepsismultidrug-resistant organismsantimicrobial resistanceantibioticsblood cultures |
| spellingShingle | Dina Khedr Peter Samaan Abdulrahman Abdulrazek Noha Adel Yassin The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study Pediatric Sciences Journal neonatal sepsis multidrug-resistant organisms antimicrobial resistance antibiotics blood cultures |
| title | The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study |
| title_full | The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study |
| title_fullStr | The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study |
| title_full_unstemmed | The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study |
| title_short | The Commonly Encountered Bacterial Agents and their Antibiotic Sensitivity in the Neonatal Intensive Care Units of Cairo University Children Hospitals: An Observational Study |
| title_sort | commonly encountered bacterial agents and their antibiotic sensitivity in the neonatal intensive care units of cairo university children hospitals an observational study |
| topic | neonatal sepsis multidrug-resistant organisms antimicrobial resistance antibiotics blood cultures |
| url | https://cupsj.journals.ekb.eg/article_401883_4da522b88fb188aec0a994d13136f3e6.pdf |
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