Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocytes

Extracellular vesicles from fifth-stage larval Angiostrongylus cantonensis upregulate cholesterol biosynthesis and suppress NLRP2-associated inflammatory responses in mouse astrocytes

ABSTRACT Angiostrongylus cantonensis is a zoonotic parasite that causes severe symptoms in humans, including eosinophilic meningitis and eosinophilic meningoencephalitis. Extracellular vesicles (EVs) derived from helminthes have been implicated in regulating host survival and immune response. Howeve...

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Bibliographic Details
Main Authors: Chien-Ju Cheng, Lian-Chen Wang, Lichieh Julie Chu, Kuang-Yao Chen, Ching-Yun Huang, Kuo-Lun Lan, Kuo-Yang Huang
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSystems
Subjects:
Angiostrongylus cantonensis
extracellular vesicles
host-parasite interaction
cholesterol synthesis
NLRP2 inflammasome
Online Access:https://journals.asm.org/doi/10.1128/msystems.01014-24
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