干扰素-α对骨髓增殖性肿瘤JAK2V617F基因表达的影响
【目的】 研究干扰素-α在治疗骨髓增殖性肿瘤(MPN)中的疗效及对JAK2V617F基因表达的影响【方法】 分析73例应用干扰素-α治疗超过6个月的MPN患者的临床资料及JAK2V617F基因表达,并与同期单用羟基脲治疗的20例MPN做对照治疗前后采用AS-PCR方法检测JAK2V617F基因表达【结果】 干扰素-α治疗组中真性红细胞增多症原发性血小板增多症分别有85.2 %87 %达到完全或部分缓解(与对照组单用羟基脲治疗比较,P < 0.01)随访1 ~ 6年,56例干扰素-α治疗组的真性红细胞增多症原发性血小板增多症JAK2V617F突变基因转阴率分别为54%41%,转阴患者100...
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Format: | Article |
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Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2011-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
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Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43577748/ |
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