Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking

Revisiting the Metabolism of Donepezil in Rats Using Non-Targeted Metabolomics and Molecular Networking

<b>Background/Objectives</b>: Although donepezil, a reversible acetylcholinesterase inhibitor, has been in use since 1996, its metabolic characteristics remain poorly characterized. Therefore, this study aims to investigate the in vivo metabolism of donepezil using liquid chromatography–...

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Bibliographic Details
Main Authors:	Eun-Ji Park, Eui-Hyeon Kim, Ki-Young Kim, Ji-Hyeon Jeon, Im-Sook Song, So-Young Park, Kwang-Hyeon Liu
Format:	Article
Language:	English
Published:	MDPI AG 2025-01-01
Series:	Pharmaceutics
Subjects:	donepezil mass spectrometry metabolism molecular networking nontargeted metabolomics
Online Access:	https://www.mdpi.com/1999-4923/17/1/115
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