Kratom Alkaloids: A Blood–Brain Barrier Specific Membrane Permeability Assay-Guided Isolation and Cyclodextrin Complexation Study

Kratom Alkaloids: A Blood–Brain Barrier Specific Membrane Permeability Assay-Guided Isolation and Cyclodextrin Complexation Study

Mitragynine is an “atypic opioid” analgesic with an alternative mechanism of action and a favorable side-effect profile. Our aim was to optimize the alkaloid extraction procedure from kratom leaves and to determine and isolate the most relevant compounds capable of penetrating the central nervous sy...

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Main Authors: András Dohárszky, Erika Mária Vági, Árpád Könczöl, Alexandra Simon, Erzsébet Várnagy, Miras Muratov, Kristóf István Steiger, Bianka Várnai, Szabolcs Béni, Eszter Riethmüller, Ida Fejős
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
indole alkaloids
extraction
parallel artificial permeability assay
blood–brain barrier permeability
inclusion complexes
complex stability
Online Access:https://www.mdpi.com/1420-3049/29/22/5302
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