Hippocampal SIRT1 signaling mediates the ameliorative effect of treadmill exercise on anxiety- and depression-like behavior in APP/PS1 mice

Hippocampal SIRT1 signaling mediates the ameliorative effect of treadmill exercise on anxiety- and depression-like behavior in APP/PS1 mice

ObjectiveAnxiety and depression-like symptoms occur in the early stages of Alzheimer’s disease. Hippocampal Sirtuin 1 (SIRT1) signaling mediates anxiety- and depression-like behavior. Exercise training improves anxiety and depression-like behavior in various disease models, such as the rat chronic r...

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Bibliographic Details
Main Authors: Yarong Wang, Rongxing Zhang, Yumin Jiang, Jingwen Liao, Lianwei Mu, Min Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
SIRT1
treadmill exercise
anxiety-and depression-like behaviors
mitochondrial
APP/PS1 mice
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1489214/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1489214/full

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