Cancer specific up-regulated lactate genes associated with immunotherapy resistance in a pan-cancer analysis

Cancer specific up-regulated lactate genes associated with immunotherapy resistance in a pan-cancer analysis

Background: Although the lactate pathway has been reported to lead to immune escape through the inhibition of effector T cells, the cancer-intrinsic lactate signature has not been identified, and the immunotherapeutic efficacy and potential mechanism of the lactate signature are still unclear. Metho...

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Main Authors: Shuiting Fu, Jiachen Xu, Chunming Wang, Cheng Zhang, Chengcheng Li, Wenchuan Xie, Guoqiang Wang, Xin Zhu, Yuyan Xu, Yaohong Wen, Jingyuan Pei, Jun Yang, Mingyang Tang, Hongkun Tan, Shangli Cai, Lei Cai, Mingxin Pan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Lactate
Immunosuppression
Immune checkpoint inhibitor
Cancer intrinsic feature
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024155223
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http://www.sciencedirect.com/science/article/pii/S2405844024155223

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