Comprehensive interaction modeling with machine learning improves prediction of disease risk in the UK Biobank

Abstract Understanding how risk factors interact to jointly influence disease risk can provide insights into disease development and improve risk prediction. Here we introduce survivalFM, a machine learning extension to the widely used Cox proportional hazards model that enables scalable estimation...

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Bibliographic Details
Main Authors: Heli Julkunen, Juho Rousu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61891-y
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