Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation

Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation

Abstract Natural killer (NK) cell function is regulated by a balance of activating and inhibitory signals. Tumor necrosis factor (TNF) is an inflammatory cytokine ubiquitous across homeostasis and disease, yet its role in regulation of NK cells remains unclear. Here, we find upregulation of the immu...

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Main Authors: Timothy R. McCulloch, Gustavo R. Rossi, Louisa Alim, Pui Yeng Lam, Joshua K. M. Wong, Elaina Coleborn, Snehlata Kumari, Colm Keane, Andrew J. Kueh, Marco J. Herold, Christoph Wilhelm, Percy A. Knolle, Lawrence Kane, Timothy J. Wells, Fernando Souza-Fonseca-Guimaraes
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54232-y
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https://doi.org/10.1038/s41467-024-54232-y

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