Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Synergistic effect of umbilical cord extracellular vesicles and rhBMP-2 to enhance the regeneration of a metaphyseal femoral defect in osteoporotic rats

Abstract Background The aim of this study was to evaluate potential synergistic effects of a single, local application of human umbilical cord MSC-derived sEVs in combination with a low dose of recombinant human rhBMP-2 to promote the regeneration of a metaphyseal femoral defect in an osteoporotic r...

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Bibliographic Details
Main Authors: Amelie Deluca, Andrea Wagner, Patrick Heimel, Christian Deininger, Florian Wichlas, Heinz Redl, Eva Rohde, Herbert Tempfer, Mario Gimona, Andreas Traweger
Format: Article
Language:English
Published: BMC 2024-05-01
Series:Stem Cell Research & Therapy
Subjects:
BMP-2
Extracellular vesicles
Exosomes
Drug delivery; osteoporosis
Metaphyseal defect
Online Access:https://doi.org/10.1186/s13287-024-03755-8
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