Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition

Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition

Abstract Hypoxia-inducible factor 1α (HIF-1α) is a master regulator of cellular adaptation to hypoxia. Although prolyl hydroxylation-mediated degradation via the von Hippel–Lindau (VHL) ubiquitination complex is a well-established regulatory mechanism, the role of lactate-induced posttranslational m...

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Bibliographic Details
Main Authors: Chengyu Li, Chen Fu, Wenhan Zhou, Hongmin Li, Zhaojun Liu, Gang Wu, Tong He, Ming Shen, Honglin Liu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Cell Communication and Signaling
Subjects:
HIF-1α
Lactate
Lactylation
Ubiquitination
Hydroxylation
VHL
Online Access:https://doi.org/10.1186/s12964-025-02366-x
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https://doi.org/10.1186/s12964-025-02366-x

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